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Technology

Optical Mapping is a de novo process that generates whole genome, ordered, restriction maps with no requirement for previous sequence information. Whole genome analysis may be performed on bacteria, yeast or fungi. Where current technologies like microarray or SNP genotyping systems detect small changes in DNA sequence, Optical Mapping can find the unexpected — genomic rearrangements and modifications to genomic architecture and novel discovery, independent of prior sequence information.

Discover differences other technologies miss: regions of similarity appear in blue, differences in white.

Technology Applications

Comparative Genomics

For analyzing and comparing genomes from different strains to better understand gene function and relatedness.

Find insertions, deletions, and intragenomic reshuffling of segments of genomic sequences such as inversions, transpositions, duplications and rearrangements. Identify and track mobile genetic elements like phage and transposons. more >

 

Whole Genome Sequence Assembly

For accelerating sequence assembly by aligning sequence contigs to an Optical Map scaffold to rapidly order and orientate sequences.

Misassemblies can be identified, corrected and orientated properly to rapidly locate and close gaps. Complementary to sequencing technologies, Optical Mapping is used to survey genomic architecture prior to sequencing, thereby reducing the number sequence runs required for whole genome analysis. Additionally, Optical Mapping is an independent validation method for sequencing projects. more >

 

Strain Typing and Epidemiology

For strain characterizing and monitoring strain stability, determining genetic relatedness between multiple microbial isolates, and differentiating and visualizing genomic differences between the strains.

Optical mapping tracks and links outbreak or potential contamination strains to the responsible source. more >