 |  | |
|
Welcome Company Overview Core Principles Board of Directors OpGen Team Investor Relations Terms of Use Privacy | ||
 |  |
| | |
|
Overview What Is Optical Mapping? MapSolver™ Comparative Genomics Whole Genome Sequence Assembly Strain Typing Food Microbiology Epidemiology / Food Safety Bibliography | ||
| |
| | |
|
Argus® Optical Mapping System MapIt® Services - Sample Preparation - Sample Transport - Request a MapIt Quote - Payment + Terms | ||
| |
Technology: MapSolver™
MapSolver, OpGen’s proprietary software is a powerful, highly functional, analysis tool for evaluating Your Optical Maps in the following ways:
To View Your Optical Maps (slide 1)
- Whole genome Optical Maps are visually displayed, showing all restriction cut sites.
- Properties including the length of the Map, total # of fragments, # of features, and # of alignments drawn to the Map can be accessed.
- Motifs can be identified, features annotated, and sequence data viewed from in silico maps.
To Compare Optical Maps to Each Other, and to in silico Sequenced Genomes (slide 2)
- Whole or partial genome Maps may be compared between related organisms.
- Similarities and Differences are highlighted and can be accessed for more detail: insertions, deletions, repetitive sequences, palindromes etc.
- Features such as genes unique to the in silico map, not present in Your Optical Map maybe viewed using sequence annotation.
- Searches may be performed among Your Maps for an interesting unique restriction pattern, looking for regions similarity.
- Map-based clustering distinguishes strains and describes relatedness between Mapped isolates.
To Place and Align Sequence Contigs, and Facilitate Closure (slide 3)
- Sequence contig data can be uploaded into the database allowing You to view your sequenced contigs.
- Sequence contigs will place along the Map in regions where restriction patterns match that of the Optical Map — this occurs in less than a minute.
- Inversions are easily viewed and can be corrected to align the Map properly.
- After contigs are aligned, gap size and location is visualized and can be determined.
- Gap closure techniques such as designing PCR primers is easy and straight forward.
To Document and Continue Your Work
- Optical Maps, and all changes made like features and annotations, alignments, addition of more sequence contigs etc. may be saved anywhere on your computer.
- Files can be selected again, to complete unfinished work easily.
- File formats include .xml and .fasta. Graphics and data can be easily exported to post script files or .csv files for further analysis.