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MapSolver™

Whole Genomes in Plain View

MapSolver™ genome analysis software provides a comprehensive view of whole-genome architecture and visual, side-by-side comparisons of maps and sequence data.

1. View Whole Genome Maps

2. Assemble, Finish and Validate Genome Sequences

3. Compare Map Data

4. Create Similarity Clusters

5. Manage Data

View Whole Genome Maps

Create in silico maps from sequence data
Identify and annotate motifs

Review map statistics (click here to see the features)

Genome-wide restriction cut sites
Gap size and location
# of features and annotation
# of Whole Genome Map alignments
# of restriction fragments
2-150 of map comparisons
Genomic rearrangements
In silico map sequence data

Indels
Mobile elements
Phages
Repetitive sequences
Sequence contigs
Sequence data
Transposons
Virulence motifs

Assemble, Finish and Validate Genome Sequences

Align in silico restriction maps of sequence contigs to the Whole Genome Map in less than a minute.

Order and orient contigs
Identify mis-assemblies
Locate and measure gaps for probe design
Calculate assembly statistics

Video Tutorial: Sequence Assembly

Compare Map Data

Compare Whole Genome Maps and in silico maps (from imported sequence data)

Highlight similarities and differences
Zoom in for more detail: insertions, deletions, repetitions, etc.
Identify novel elements
Searches for unique restriction patterns
Distinguish strains and determine relatedness between isolates

Video Tutorial: Comparative Genomics

Create Similarity Clusters

Illustrate relative differences between the maps
Display % difference

Video Tutorial: Cluster Creation

Manage Data

Save and retrieve maps, annotations, alignments and all other edits
Export graphics and data into postscript or .csv files for further analysis
Import other sequence data (.xml or .fasta)

Video Tutorial: Data Interpretation

“Physical map and genetic map still should be emphasized as an important parts of a reference genome. Recent progress in technologies, such as the whole genome mapping high-throughput platform offered by OpGen, now provide the tools for efficient physical map construction. This independent technology provides not only the validation of the genome sequencing, but also provides the large-scale chromosome structure information that cannot be detected by sequencing. We applied this technology as an assistant tool of the NGS to assemble bacterial, plant and large mammalian genome with reliable accuracy and generate the sub-chromosome graded assembly. The experience in these genome assembly projects shows that the physical map should be the standard for any reference genome to be assembled in further.”

Xun Xu, Ph.D.

Deputy Director at BGI

This independent technology provides not only the validation of the genome sequencing, but also provides the large-scale chromosome structure information that cannot be detected by sequencing.

Xun Xu, Ph.D.
Deputy Director at BGI

“Our research focuses on a wide variety of projects from viruses and microbes to crop plants and mammals. Many of our projects are de novo assembly projects, where, without a closely related genome sequence, it can be difficult to critically assess the results. We often combine different sequencing technologies, and we are finding that regardless of the sequencing platform, error correction, or assembler used, OpGen’s Whole Genome Mapping identifies misassemblies and provides the highest quality de novo assembly for further research.”

Matthew Clark, Ph.D.

Team Leader, Sequencing Technology Development

The Genome Analysis Centre (TGAC), Norwich, UK

OpGen’s Whole Genome Mapping identifies misassemblies and provides the highest quality de novo assembly for further research.

Matthew Clark, Ph.D.
Team Leader, Sequencing Technology Development

“We adopted OpGen’s Argus System as the most advanced way of adding Whole Genome Mapping to improve whole genome sequences. We combined Whole Genome Maps with sequence assemblies to correct errors and misassemblies in bacterial genome sequences as part of our program in the Human Microbiome Project. We are now moving the technology into larger genome projects.” 

George Weinstock, Ph.D.

Associate Director  The Genome Institute at Washington University

We combined Whole Genome Maps with sequence assemblies to correct errors and misassemblies in bacterial genome sequences. This is part of our program from the Human Microbiome Project.

George Weinstock Ph.D.
 Associate Director 
The Genome Institute at Washington University

“Certain things you just have a tough time answering with de novo sequencing. And assembly doesn’t always work out as sweetly as you would like. So definitely for any whole genome de novo project that people are insistent on closing we would do a Whole Genome Map optically as well as de novo assembly. And the amount of money you would save is in the thousands of dollars in finishing.”

Stefan Green

Director of DNA Services

University of Illinois Chicago Research Resources Center (UIC RRC)

Definitely for any whole genome de novo project that people are insistent on closing we would do a Whole Genome Map.

Stefan Green
Director of DNA Services