Comparative Genomics

Genome Differences in Plain View. 

Comparing two or more genomes is fast and easy with Whole Genome Mapping (WGM) technology and advanced analysis tools. Fast and easy to use, the maps allow you to see and compare genomic content with higher accuracy across the entire genome.

Even highly related organisms can be accurately analyzed to confirm the similarities and locate regions that are different (Figure 1). These differences can be challenging to detect genomic variation or mobile elements. Locating these differences with WGM technology directs specific studies of annotated genes in the sequence that aligns to the areas of difference (Figure 2).

Figure 1. P. aeruginosa ATCC 27317 compared to sequenced Liverpool epidemic strain LESB58.
Prophages and genomic islands (LESGI) identified in the sequenced isolate are indicated (red). Closer examination of prophage 3 locus (Detailed view) indicates  absence of the prophage in ATCC 27317.

• Find genetic variation: insertions, deletions and other genetic modifications
• Track mobile elements inclusing pathogenicity islands, phage and transposons
• Differentiate strains and genetic relatedness between multiple isolates 

Figure 2. Large insertion detected in multi-drug resistant strain

OpGen provides proprietary software called MapSolver™ to analyze the sequences and compare maps with a high level of accuracy. You can take advantage of Whole Genome Mapping and high definition analysis with a MapIt Service map analysis of your samples. Or you can bring the Argus Whole Genome Mapping System into your lab to process samples and analyze multiple-map comparison and cluster analysis.