One Genome. One Image.
The Answers Are Right Before Your Eyes.
Whole Genome Mapping simplifies genomics research with a high definition view of the entire genome. The result is an ordered picture that provides the answers you need to accelerate your assembly and comparative genomics projects–and with more confidence in the accuracy of the data.
- Compare multiple Whole Genome Maps and related isolates
- Find differences in the maps
- Look at annotated genes in the sequence that align to the different areas
Improving Genome Sequence Assembly (<100Mb)
Genome assembly is a computational challenge. Contig order, gaps and repetitive regions are known problems, and additional finishing with libraries is expensive. Whole Genome Maps added to assembly workflows provides finished assembly in twenty-four hours–de novo assembly or maps used as a reference scaffold for accurately orienting sequence contigs.
Single-molecule Maps Complete Large Genomes (>100 Mb)
DNA assembly for larger genomes (>100 Mb) presents even more challenges–size and complexity of the sequence, downstream finishing and significant bioinformatics required. OpGen’s new Genome-Builder™ software improves sequence assembly in plants, animals and human genomes. With as little as one to two weeks for assembly, potentially 90% of scaffold gaps may be joined without BAC libraries, fosmids and extensive resequencing.
Comparative Genomics at a New Level
Even the best sequencing efforts can result in sequence gaps, assembly errors and structural changes that go undetected. These challenges compromise the detection and understanding of differences between similar genomes. The linear and visual nature of Whole Genome Maps provides a highly accurate and reproducible method for detecting these differences between strains and species.
Align: Our Whole Genome Map provides a scaffold for easier, more accurate genome assembly—simplifying the alignment and ordering of contigs.
Compare: The differences between strains and species are quickly and easily seen with Whole Genome Maps. Chromosomal rearrangements such as insertions, duplications, deletions, and inversions are readily identified in a single glance.
Confirm: Accurate genome assemblies are confirmed and misassemblies and gaps identified through alignment with our Whole Genome Map.